The countdown is now less than two weeks away, with Los Angeles and Buffalo all set to open up the NFL season on Thursday, Sept. 8. People can’t wait for this epic showdown, as the two sides will be ready to put on a show. This article has NFL picks for Bills vs. Rams on Opening Night. Which of these two squads will be able to start the campaign with a bang?
It might surprise some people, but the Bills are the favorites to record a win in this one. Despite LA being the home team for this Week 1 matchup, the Bills hold the No. 1 Super Bowl betting odds leading up to the new season. That’s because Josh Allen is one of the best quarterbacks in the game, and the team only got stronger thanks to the addition of pass-rusher Von Miller.
Buffalo has come close to the Super Bowl the past two seasons, losing the Kansas City Chiefs in the postseason in back-to-back years. Now, though, there’s an immense feeling that this will end up being Buffalo’s year. The Rams will hope to stand in the way of things, though, as LA won the Super Bowl last season. They want to repeat as champs. Below are the odds from the top-rated NFL betting sites.
| Bills-Rams odds |  |  |  |  |
|---|---|---|---|---|
| Bills to win | -134 | -134 | -134 | -134 |
| Rams to win | +114 | +114 | +114 | +114 |
| Over to hit | -110 | -110 | -110 | -110 |
| Under to hit | -110 | -110 | -110 | -110 |
The Rams made plenty of noise this offseason, too, as they could sign Bobby Wagner. No one expected the Rams to win the Super Bowl last year, but they once again have strong NFL betting odds leading up to the 2022 season getting underway. This will make Week 1 even more intriguing, with people counting down the minutes for the kickoff to arrive.
According to the best-rated sportsbooks – check out the reliable Bovada review, for example – the Bills hold -134 odds to record a win, while the Rams have been set at +114. This will be a memorable battle, but we think the Bills will record the victory at the end of the night. We’re going with Buffalo as our pick to win.
It goes without saying, but expect plenty of points in the Rams vs. Bills showdown in early September. Both of these offenses are loaded; there’s no doubt about that. Starting with the Bills, things, of course, begin with Allen. He is one of the top quarterbacks in the game and will be in the Most Valuable Player conversation throughout the season.
Allen has an unreal right arm but can also make things happen with his legs. Because of his dual-threat abilities, he’s a nightmare for opposing defenses to try and contain. Besides that, the Bills have guys like Stefon Diggs ready to make a big-time splash. Diggs is among the best wideouts in the game, and he’s motivated to have a big year.
As for the Rams, Stafford is still riding the high of winning the Super Bowl last year with the NFC West squad. He never even won a postseason game with the Detroit Lions. It was a memorable first year for Stafford with the Rams, leading to a Lombardi Trophy and a contract extension from the front office to boot. Not bad for the veteran signal-caller, who could one day see himself in the Hall of Fame as well.
In addition to Stafford, Cooper Kupp is a playmaker for the Rams – and he’s one of the top wide receivers out there too. Look for Stafford and Kupp to keep things rocking. Per the oddsmakers, the over/under for this contest has been set at 52.5 points. Both the over and under is set at -110. From our chair, we’re expecting a lot of issues in this one. Go with the above for the LA-Buffalo meeting; that’s our pick for this matchup.
In terms of player props, it’s also our expectation that Josh Allen will top 300 yards passing vs. the Rams in this primetime game. Allen will always get attention for his running abilities, but you must remember that he also passed for more than 4,000 yards last season. That was incredible for the Bills, head coach Sean McDermott, and former offensive coordinator Brian Daboll.
Now, more of the same is expected from Allen in 2022. The Rams’ defense sure is strong, but their secondary is no stranger to giving up big plays from time to time. With Buffalo’s explosive offense, Allen throwing for 300 yards should happen with no issues. The odds of Allen hitting at least 300 yards through the air have been set at -125. No way doesn’t happen. Go with him topping that number, and he’ll do so with ease.
